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 Formulary Chapter 4: Central nervous system - Full Chapter
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04.03.04  Expand sub section  Other antidepressant drugs
Venlafaxine
(Adult Depression)
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Restricted Drug Restricted
Green
Tablets and capsules 37.5mg, 75mg, 150mg.
  • Usual dose range 37.5-75mg twice daily
  • Max daily dose 375mg 
  •    
    Agomelatine
    (Adult depression)
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    Restricted Drug Restricted
    Green
    Tablets 25mg
  • Usual dose range 25-50mg daily
  • Max daily dose 50mg
  • Max single dose 50mg 
  •    
    Duloxetine (Cymbalta)
    (Adult Depression)
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    Restricted Drug Restricted
    Green
    Capsules 30mg and 60mg
  • Usual dose range 60mg daily
  • Max daily dose 60mg
  • Max single dose 60mg 
  •    
    Flupentixol (Fluanxol)
    (Adult Depression)
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    Restricted Drug Restricted
    Green
    Tablets 0.5mg, 1mg
  • Usual dose range 1-3mg
  • Max daily dose 3mg
  • Max single dose 2mg 
  •    
    Reboxetine (Edronex)
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    Restricted Drug Restricted
    Green
    Tablets 4mg
  • Usual dose range 4mg twice daily
  • Max daily dose 12mg
  • Max single dose 6mg 
  •    
    Tryptophan
    (Adjunct for Adult Depression)
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    Restricted Drug Restricted
    Red
    Tablets 500mg
    Adjunct for Adult Depression
  • Usual dose range 3-6grams daily in three divided doses
  • Max daily dose 6grams
     
  •    
    Venlafaxine (Efexor XL)
    (Adult Depression)
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    Restricted Drug Restricted
    Green
    Tablets and Capsules, MODIFIED RELEASE 75mg, 150mg
  • Usual dose range 75-225mg once daily
  • Max daily dose 225mg
  • Max single dose 225mg 
  •    
    Duloxetine (Cymbalta)
    (General Anxiety Disorder)
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    Restricted Drug Restricted
    Green
    Capsules 30mg and 60mg
  • Usual dose range 30-60mg daily
  • Max daily dose 120mg
  • Max single dose 120mg 
  •    
    Duloxetine (Yentreve)
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    Restricted Drug Restricted  
       
    Mirtazapine
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    Formulary
    Green
    Tablets 15mg, 30mg and 45mg
    Orodispersible tablets also avaialable 
       
     ....
     Non Formulary Items
    Mirtazapine  (Zispin® SolTab)

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    Non Formulary
     
      
    Key
    note Notes
    Section Title Section Title (top level)
    Section Title Section Title (sub level)
    First Choice Item First Choice item
    Non Formulary Item Non Formulary section
    Restricted Drug
    Restricted Drug
    Unlicensed Drug
    Unlicensed
    Track Changes
    Display tracking information
    click to search medicines.org.uk
    Link to adult BNF
    click to search medicines.org.uk
    Link to children's BNF
    click to search medicines.org.uk
    Link to SPCs
    SMC
    Scottish Medicines Consortium
    Cytotoxic Drug
    Cytotoxic Drug
    CD
    Controlled Drug
    High Cost Medicine
    High Cost Medicine
    Cancer Drugs Fund
    Cancer Drugs Fund
    NHSE
    NHS England
    Homecare
    Homecare
    CCG
    CCG

    Traffic Light Status Information

    Status Description

    Amber

    Medicines suitable to be prescribed in primary care after Specialist* recommendation or initiation. A supporting prescribing guideline may be requested which must have been agreed by the relevant secondary care trust D&TC(s). *Specialist is defined as a clinician who has undertaken an appropriate formal qualification or recognised training programme within the described area of practice.   

    Amber 1

    Medicines that should be initiated by a specialist and prescribed by primary care prescribers only under a shared care protocol, once the patient has been stabilised. Prior agreement must be obtained by the specialist from the primary care provider before prescribing responsibility is transferred. The shared care protocol must have been agreed by the relevant secondary care trust Drugs and Therapeutics Committee(s) (D&TC) * All drugs awaiting the production or approval of a shared care guideline default to RED   

    Cancer Drug Fund

    Cancer Drug Fund   

    Green

    Medicines suitable for routine use and can be prescribed within primary care within their licensed indication, in accordance with nationally recognised formularies, for example the BNF, BNF for Children, Medicines for Children or Palliative Care Formulary. Primary care prescribers take full responsibility for prescribing.  

    Green Specialist Initiation

    These drugs should be initiated only by a hospital or specialist clinician (GPSi) but there is no requirement for additional monitoring over the general requirements for all medicines. Some may require short or medium specialist monitoring of efficacy or dose titration before transferring in Primary care. The GP should have all the information they require to support continued prescribing.   

    Green Specialist Recomendation

      

    Grey

    Grey - Medicines, which the Drug & therapeutics Committee has actively reviewed and does not recommend for use at present following a review of clinical and/or cost effective data. Grey (assessment in progress) - will be reviewed at a future D&T meeting. Grey (awaiting submission) - The D&T are awaiting a submission from an appropriate practitioner. If you wish to make a submission for this medicine to be added to the formulary please email drug.information@bthft.nhs.uk .   

    Non Formulary

    Not recommended for prescribing as initial therapy, but can be continued if patient already stable on treatment   

    Red

    Medicines which should normally be prescribed by specialists only. ** For patients already receiving prescriptions in primary care - continue. No new patients to receive prescriptions in primary care   

    RED ULM

    Unlicensed Medication  

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